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Over time the connection get gummed up with dirt or are pulled when the seat is moved. Before you done anything else, push the seats back, find the cable under the seats, disconnect the cable, clean up the connectors and then re-attach
If it is powering up, are you getting anything at all noise wise coming out of the speakers ? (hissing or clicking when you turn the ignition on/off) Starting the car will turn the unit off then back on again.